Discovery of a Novel Class of Boron - based Antibacterials 1 with Activity against Gram - negative Bacteria
نویسندگان
چکیده
3 Vincent Hernandez, Thibaut Crépin, Andrés Palencia, Stephen Cusack, Tsutomu Akama, 4 Stephen J. Baker, Wei Bu, Lisa Feng, Yvonne R. Freund, Liang Liu, Maliwan Meewan, 5 Manisha Mohan, Weimin Mao, Fernando L. Rock, Holly Sexton, Anita Sheoran, Yanchen 6 Zhang, Yong-Kang Zhang, Yasheen Zhou, James A. Nieman, Mahipal Reddy Anugula, El 7 Mehdi Keramane, Kingsley Savariraj, D. Shekhar Reddy, Rashmi Sharma, Rajendra Subedi, 8 Rajeshwar Singh, Ann O’Leary, Nerissa L. Simon, Peter L. De Marsh, Shazad Mushtaq, 9 Marina Warner, David M. Livermore, M. R. K. Alley, Jacob J. Plattner 10 11
منابع مشابه
Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria.
Gram-negative bacteria cause approximately 70% of the infections in intensive care units. A growing number of bacterial isolates responsible for these infections are resistant to currently available antibiotics and to many in development. Most agents under development are modifications of existing drug classes, which only partially overcome existing resistance mechanisms. Therefore, new classes...
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